WebNatural terpene quinone methides (QM) and their derivatives have been investigated as therapeutics due to their broad antifungal, antibacterial, and antitumor activities. Recently, we reported that a terpene QM was formed from the catechol precursor through the disproportionation of Cu(II)/(I) redox cycle, and extensive DNA damage was observed … Web(Figure presented) A novel C 35-terpene, designated as cryptotrione (1), with an unprecedented skeleton possessing an abietane diterpene with a unique bicyclic sesquiterpene, is identified from the bark of Cryptomeria japonica.The carbon skeleton of 1 represents a new structural entity, and this is an intriguing addition to the structurally …
Vanessa Kar-Yan Lo
WebThe total synthesis of cryptotrione (1) was enabled by substrate‐controlled diastereoselective construction of the bicyclo[3.1.0]hexene framework through … WebJul 21, 2024 · The total synthesis of cryptotrione (1) was enabled by substrate‐controlled diastereoselective construction of the bicyclo [3.1.0]hexene framework through … manually bring up keyboard surface
Total Synthesis of Cryptotrione - Lyu - Wiley Online Library
WebMar 1, 2024 · Request PDF On Mar 1, 2024, Zhuliang Zhong and others published Pivotal Reactions in the Creation of the Polycyclic Skeleton of Cryptotrione Find, read and cite all the research you need on ... WebCryptotrione ( 3 ), isolated from the Japanese cedar Cryptomeria japonica, showed activity against human oral epidermoid carcinoma KB cells. Henry N. C. Wong and Xiao-Shui Peng of the Chinese University of Hong Kong assembled the tetracyclic core 2 of 3 by the diastereoselective cyclization of the alkyne 1 ( Angew. Chem. Int. Ed. 2024, 59, 19929. WebTotal Synthesis of Cryptotrione Angew. Chem. Int. Ed. 2024, DOI: 10.1002/anie.202409255. Synthesis of (±)-Cryptotrione Significance: Cryptotrione was isolated from the bark of Cryptomeria japonica in 2010. It has antican-cer activity against human oral epidermoid carcino-ma KB cells. Additionally, it consists of an unprece- manually bypass push buttons on dishwasher