Ctgf and liver fibrosis

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August undefined, 2024

WebJan 21, 2024 · CTGF is a kind of matrix protein that is commonly up-regulated in the liver fibrosis, which plays a key role in liver fibrosis (Weiskirchen, 2016; Wu et al., 2024b; Makino et al., 2024). Studies have shown that hepatocytes, bile duct cells, HSCs and many other cells express and secrete CTGF protein in the fibrotic liver ( Williams et al., 2014 ... WebFeb 7, 2012 · Liver fibrosis is a major cause of liver failure, but treatment remains ineffective. In the present study, we investigated the mechanisms and anti-hepatofibrotic activities of asiatic acid (AA) in a rat model of liver fibrosis induced by carbon tetrachloride (CCl4) and in vitro in TGF-beta1-stimulated rat hepatic stellate cell line (HSC-T6). …

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WebHepatic fibrosis, which has characteristics of excessive deposition of extra cellular matrix (ECM), occurs by various chronic liver injuries, such as from chemicals, viral infection, … WebDec 3, 2024 · Liver fibrosis is a multicellular response to liver injury in which hepatic stellate cells (HSCs) are responsible for 90% of extracellular matrix (ECM) production [1,2,3,4,5].Liver fibrosis upon acute liver injury may be beneficial by providing mechanical stability and facilitating the restoration of hepatic architecture and function. tryptophan reizdarm

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WebJan 13, 2024 · Connective tissue growth factor (CTGF) is involved in the regulation of extracellular matrix (ECM) production. Elevated levels of CTGF can be found in plasma from patients with liver fibrosis and in experimental animal models of liver fibrosis, but the exact role of CTGF in, e.g., diet-induced human liver fibrosis is not entirely known. To … WebJun 13, 2024 · Connective tissue growth factor (CTGF, also known as CCN2), a member of the CCN family of matricellular proteins, is widely known as a hallmark of fibrosis in multiple tissues, including skin, heart, lung, liver, and kidney [ 3, 4 ]. WebBackground: Connective tissue growth factor (CTGF) belongs to a family of factors that regulate fibrogenesis and wound healing. While the significance of transforming … phillip morris snus

Frontiers Novel Therapeutic Targets in Liver Fibrosis

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WebMay 28, 2024 · CTGF is a primary mediator of TGF-β-induced pulmonary fibrosis. CTGF was found to be overexpressed in fibrotic lesions in major organs, including the lung, kidney, liver, skin, cardiovascular system, gastrointestinal system, eye, and gingiva [8]. WebSep 1, 2006 · Results: The mean concentration of CTGF was highest in the fibrosis group (5.2-fold) and in the chronic viral hepatitis group (4.3-fold) but lower in those patients with fully developed cirrhosis. The area under the ROC curve (AUC) of CTGF for fibrosis vs control was 0.955 (95% confidence interval, 0.890–0.987). phillip morris real personWebAug 1, 2024 · The secretory character of CTGF and its production by various cell types in liver disease makes it a potential biomarker for the diagnosis of liver fibrosis and its progression. Several clinical studies have demonstrated significantly increased serum or plasma CTGF in patients with fibrotic/cirrhotic liver disease. tryptophan regulation

"WebLong-term injury to liver cells and consistent activation of the fibrogenic response can lead to liver fibrosis such as that seen in chronic alcoholics or clinically obese individuals. … " - Ctgf and liver fibrosis

Ctgf and liver fibrosis

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WebDec 5, 2024 · These observations demonstrate conserved cross-species functions of Ccn2/Ctgf protein in rodent livers. This protein can be induced in hepatocytes and … WebNov 1, 2024 · Paracrine factors such as platelet-derived growth factor (PDGF), transforming growth factor β (TGFβ), and connective tissue growth factor (CTGF), together with other growth factors and cytokines/chemokines, activate cellular signaling pathways of cell proliferation, migration, ECM protein secretion, and contractility that promote …

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WebAug 22, 2024 · Accordingly, hepatic fibrosis occurs when liver is repeatedly and continuously injured. Damage to hepatocytes triggers the release of reactive oxygen species (ROS) and inflammatory mediators, which would stimulate carcinogenic process . Untreated fibrosis may progress to liver cirrhosis, leading to organ failure and hepatoma [3,4]. … WebConnective tissue growth factor (CTGF) plays a critical role in the hepatic stellate cells (HSCs)-mediated development of hepatic fibrosis. Nevertheless, the effects of CTGF …

WebOct 3, 2024 · Organ fibrosis often ends in eventual organ failure and leads to high mortality. Although researchers have identified many effector cells and molecular pathways, there are few effective therapies for fibrosis to date and the underlying mechanism needs to be examined and defined further. Epoxyeicosatrienoic acids (EETs) are endogenous lipid … WebHepatic fibrosis, which has characteristics of excessive deposition of extra cellular matrix (ECM), occurs by various chronic liver injuries, such as from chemicals, viral infection, and alcoholic or nonalcoholic hepatic steatosis [].Although the pathogenesis of hepatic fibrosis is not revealed clearly, hepatic stellate cells (HSCs) are believed to be a major role in the …

WebMay 8, 2024 · Connective tissue growth factor (CTGF) associated with transforming growth factor-β (TGF-β) play a pivotal role in the pathophysiology of many fibrotic disorders. … WebFeb 1, 2011 · Connective tissue growth factor (CTGF) is widely thought to promote the development of fibrosis in collaboration with transforming growth factor (TGF)-β; however, most of the evidence for its involvement comes from correlative and culture-based studies.

WebJan 8, 2024 · Carbon tetrachloride (CCl4) is widely used to induce hepatic fibrosis. Therapeutic agents alleviate hepatic fibrosis by inhibiting signal transducer and activator …

WebJan 12, 2011 · Increased levels of CTGF have also been observed in experimental models of lung fibrosis. In addition, CTGF can cause susceptibility to experimentally-induced … phillip morris spinoffsWebFeb 16, 2024 · Connective tissue growth factor (CTGF) expression in hepatic stellate cells (HSCs) and liver endothelial cells correlates with the extent of acute liver injury, and … phillip morris steven russellWeb氯雷他定是一种h1受体阻滞剂，具有抗炎、抗过敏、抗氧化等药理作用。有研究结果表明，氯雷他定对于急性肝损伤有保护作用 [] ，但评估氯雷他定对于慢性肝损伤造成的肝纤维化的影响报道尚少。本研究利用脂多糖制备大鼠肝纤维化模型，探究氯雷他定对大鼠肝纤维化的作用及其机制。 phillip morris strict liabilityWebJan 12, 2011 · In patients with IPF, CTGF levels are elevated in transbronchial biopsy specimens and in bronchoalveolar lavage fluid. Increased levels of CTGF have also been observed in experimental models of lung fibrosis. In addition, CTGF can cause susceptibility to experimentally-induced lung fibrosis in otherwise resistant mice. tryptophan relative nutritional deficiencyWebMar 20, 2024 · Liver fibrosis (LF) is caused by chronic liver injury from various causes, such as viral infections, alcohol consumption, non-alcoholic fatty liver disease (NAFLD), … phillip morris special blend cigarette tinWebDec 3, 2024 · Liver fibrosis is a multicellular response to liver injury in which hepatic stellate cells (HSCs) are responsible for 90% of extracellular matrix (ECM) production … phillip morris smokeless tobacco phillip morris richmond warehouse