WebHypoxia-inducible factor-1 (HIF-1), a heterodimeric (containing α and β subunits) transcription factor, is involved in hypoxia response pathway that regulates the expression of many tumorrelated genes. The stabilized HIF-1 heterodimer couples to the general co-activators p300/CBP (CREB binding protein), forming an active transcription factor to … Web13 de nov. de 2002 · Full HIF induction requires the interaction of the C-terminal transactivation domain (CTAD) with coactivators such as CBP/p300 to recruit the …
An essential role for p300/CBP in the cellular response to hypoxia
WebHIF-1α在低氧(氧浓度<5%)等条件下稳定性增加,从而在细胞内蓄积并转位到细胞核内与HIF-1β形成异二聚体;然后募集 HIF辅激活复合物成分(如p300),进而与目标基因启动区的顺式低氧反应元件(cis-acting hypoxia responsive elements,HREs)结合,从而启动靶基因的 … WebThe HIF-1α/p300 protein-protein interaction plays a key role in tumor metabolism and thus represents a high value target for anticancer drug-development. Although several studies … highlights motogp aragon
缺氧誘導因子 - 维基百科,自由的百科全书
WebDownload scientific diagram p300 phosphorylation mediates AMPK effects on HIF-1 activity from publication: Definition of a Novel Feed-Forward Mechanism for Glycolysis … Web18 de fev. de 2024 · In contrast, a p300 fragment that binds to p53 but not to HIF-1 prevents p53-dependent repression of HIF-1 activities (Blagosklonny et al., 1998; Ye et al., 2024). p53 with a mutation in its DNA binding domain (R273H) retains the ability to block the transactivation activity of HIF-1, whereas p53(22,23), a transcriptionally inactive double … Web19 de mar. de 2002 · 1L8C. PubMed Abstract: The cellular response to low tissue oxygen concentrations is mediated by the hypoxia-inducible transcription factor HIF-1. Under hypoxic conditions, HIF-1 activates transcription of critical adaptive genes by recruitment of the general coactivators CBP/p300 through interactions with its alpha-subunit (Hif-1 … small portable gas generator for camping