Web15 Jun 1999 · The use of MUC1-derived peptides could provide a broadly applicable approach for the development of dendritic cell-based vaccination therapies. Topics: antigens, hla-a2 antigen, peptides, tumor antigens, vaccine therapy, t-lymphocyte epitopes, human leukocyte antigens, epitopes, cytokine Web26 Jul 2016 · Different types of MUC1-peptide vaccines have been synthesized chemically to produce effective anti-MUC1 immune responses. It has been found that using MUC1 alone does not produce strong immune responses, which necessitates the use of adjuvant and/or different T and B cell epitopes.
Dendritic cell-based cancer immunotherapy targeting MUC-1
Web18 May 2010 · MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence … WebThese IgG antibodies bound both the appropriate MUC1 synthetic peptides and the cell surface expressed MUC1 mucin on murine mammary cells that had been transfected … palace v tottenham
A review on development of MUC1-based cancer vaccine
Web24 Sep 2024 · Abstract. Because of our interest in developing new hybrid peptide radioconjugates with suitable biochemical properties for multiple-receptors targeting properties that are overexpressed on many human cancers especially ovarian cancer, we have synthesized 68 Ga-NODAGA-MUC1 and 68 Ga-NODAGA-MUC1-FA hybrid … Web5 Oct 2005 · In this report, we describe the induction of similar antibodies to MUC1 glycopeptides, not only in wild-type mice but also in mice expressing the human MUC1 transgene from its own promoter. Initially, we examined humoral immune responses to the 60-mer MUC1 TR peptide with zero, two, three, and five Tn epitopes per repeat. Web27 Oct 2005 · MUC1 mucins are highly glycosylated type I glycoproteins expressed by various normal and malignant epithelial cells such as breast, kidney and ovarian cancers and hematologic malignancies including acute myelogenous leukemia (AML), multiple myeloma and some B-cell lymphoma [ 7 – 9 ]. summer crops bundle stardew valley