Ipf scrnaseq atlas

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August undefined, 2024

Web18 dec. 2024 · Generated scRNAseq atlas of E12, E14, E16, P1, P30, and adult SMG • Smgc and Bpifa2 define two proacinar populations in the developing SMG. Loss of Ybx1, Eno1, Sox11, and Atf4 associated with acinar phenotype. Gstt1 defines Kit-negative and sexually dimorphic intercalated duct cells Web12 apr. 2024 · In a recent publication in Nature Cell Biology, an integrated single-cell RNA sequencing and spatial transcriptomics strategy was used to clarify the origins and mechanisms behind cell heterogeneity in lung. The results were used to create a …

Molecular Atlas of Small Cell Lung Cancer Reveals Unusual Cell …

Web1 jun. 2024 · Optimal single-cell RNA sequencing (scRNAseq) experiments involve the rapid isolation and selection of cells with high viability, while minimizing processing and dissociation time with the aim of... WebscRNAseq study, which analyzed the transcriptomes of 24,220 cells from the upper and lower lobes of seven control and three IPF samples, identiﬁed three distinct pulmonary macrophage subsetsintheIPFlung: FABP4himacrophages, SPP1hi/MERTK … simon thackray

ScRNA-seq analysis of IPF, SSc-ILD, and control myeloid …

Web1065475 Cells. Welcome to the soon-to-be home of the Macosko mouse brain atlas, published in our bioRxiv: The cell type composition of the adult mouse brain revealed by single cell and spatial genomics. This will store the clustered single-nuclei dataset, … Web8 jul. 2024 · We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 chronic obstructive pulmonary disease (COPD) lungs. Web1772 cells were isolated from the core and shell regions of LGd from 4 Cre lines (Snap25-IRES-Cre, pan-neuronal; Slc17a6-IRES-Cre; excitatory neuron enrichment; Gad2-IRES-Cre, Slc32a1-IRES-Cre; inhibitory neuron subpopulations) Single-cell RNA-Seq was … simon thake bbc

Integrated single-cell RNA sequencing analysis reveals ... - medRxiv

ImmunoSCOPE on Twitter: "Single-cell atlas of early-stage …

Web20年9月24日发表在nature上的文章，该研究由哈佛医学院、剑桥大学和帝国理工学院等机构的科学家共同进行。该研究是人类细胞图谱计划（Human Cell Atlas）的一部分，由Chan Zuckerberg Initiative资助，计划绘制人体中每种细胞的图谱。绘制... Web27 mei 2024 · Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology and with limited therapeutic options. Over the years, progress in IPF research has been hindered by a lack... simon thamWeb8 dec. 2016 · Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA sequencing (scRNA-seq) to identify epithelial cell types and … simon thain

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Ipf scrnaseq atlas

Understanding the Pathological Formation of Extracellular Matrix …

Web14 sep. 2024 · In order to improve our understanding of cell-specific mechanisms contributing to COPD pathogenesis, we analysed single-cell RNA sequencing (scRNAseq) profiles of explanted parenchymal lung tissue from 17 subjects with advanced COPD requiring transplant and 15 control donor lungs. Web15 mrt. 2024 · The Zebrafish scRNAseq atlas should offer the ability to produce accurate gene expression profiles for cell types of interest at multiple developmental stages. We therefore aggregated the results of all six experiments from three distinct developmental …

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WebThe Approach of the Human Lung Cell Atlas: Toolbox and Resources Section: Single-Cell Transcriptomics Single-cell RNA sequencing (scRNA-seq) aims to comprehensively capture and sequence the RNA contents of a single cell, allowing a description of transcriptional … Web14 sep. 2024 · Chronic Obstructive Pulmonary Disease (COPD) pathogenesis involves a failure to maintain alveolar homeostasis due to repetitive injury and inflammation. In order to improve our understanding of cell-specific mechanisms contributing to COPD …

Web10 jul. 2024 · IPF Cell Atlas, the world’s first single-cell sequencing atlas for idiopathic pulmonary fibrosis (IPF), is now available to the public to advance research into new treatments for the condition. This comprehensive catalogue of the complexity and diversity of 35 distinct cellular populations that are abnormal in IPF patients, is the result of a ... Web8 jul. 2024 · We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 chronic obstructive pulmonary disease (COPD) lungs. Among epithelial …

Web8 mei 2024 · SchistoCyte Atlas: A Single-Cell Transcriptome Resource for Adult Schistosomes Schistosomes cause untold disease and disability in the developing world. Here, we introduce SchistoCyte Atlas, a web-based platform for exploring gene expression at single-cell resolution in adult Schistosoma mansoni. WebThe scRNAseq analysis was based on publicly available genome-wide expression data and comprises all protein-coding genes in 536 individual cell type clusters corresponding to 15 different cell type groups. A specificity classification was performed to determine the number of genes elevated in these single cell types.

Web9 sep. 2024 · We provide a single cell atlas of Idiopathic Pulmonary Fibrosis (IPF), a fatal interstitial lung disease, focusing on resident lung cell populations. By profiling 312,928 cells from 32 IPF, 29 healthy control and 18 chronic obstructive pulmonary disease (COPD) …

WebThis pipeline performs basic analysis of sc RNA-Seq data generated using the 10X genomics protocol. It produces cell x gene count matrices using the Cell Ranger software. In addition matrices for RNA velocity analysis are created using velocyto and ready to use … simon thamm simon thaslerWeb25 jan. 2024 · Recent studies have used single-cell RNA sequencing (scRNAseq) to obtain single-cell resolution and identify disease mechanisms, cellular phenotypes, and changes in alveolar niche crosstalk 8, 9 ... simon thapaWeb5 dec. 2024 · IPF Cell Atlas: Organism: Homo sapiens: Experiment type: Expression profiling by high throughput sequencing: Summary: Single Cell RNAseq of Whole Lung Dissociates from IPF, COPD and control lungs : Overall design: Exploratory analysis of … simon thackray cardiologistWeb25 mei 2024 · Similarly, studies in multiple species on pulmonary scRNAseq datasets identified 2 distinguishable capillary EC populations. 13,14,16,36,39,50,51 This consistent but unexpected observation, for which there is no corresponding report from the pre … simon thaoWebscRNAseq to Understand Effects of Drug Treatment for IPF To date, Nintedanib and Pirfenidone are the only approved drugs for treatment of IPF ( 47, 48 ). Two recent studies employed scRNAseq to investigate the effects of drug treatment on cells from IPF patients. simon thattilWeb16 sep. 2024 · In the main part, we will summarize, compare and contrast the results of recently published investigations of aging, aging-related chronic inflammation (inflammaging) and senescence (that is, cellular senescence and immunosenescence) based on single-cell RNA-sequencing (scRNA-seq). We will specifically focus on markers of cellular … simon thang