Irf6 cancer
WebApr 19, 2024 · Several genes, including IRF6 (interferon regulator factor 6), showed an upregulation after CPH treatment. We therein demonstrated that IRF6, a potential tumor suppressor, is epigenetically silenced by DNA methylation and histone modifications in UC. Restoration of IRF6 expression by CPH may be a novel therapeutic strategy in the … WebAug 8, 2024 · A 16E6 protein binding domain essential for p53 degradation played a crucial role in regulating IL-1β transcription. 16E6 blocked the p53 transcriptional regulation of Interferon Regulatory Factor 6 (IRF6), which we found was essential for …
Irf6 cancer
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IRF6 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. Similarly, IRF6 has been found to be genetically and epigenetically disregulated in Vulvar cancer. WebGenetic ablation of Ripk4 or Irf6 in mice leads to similar skin, limb, and craniofacial defects associated with epidermal hyperplasia, parakeratosis, and soft tissue fusions, as observed in humans, suggesting that the mouse models are relevant to the human disease processes [ …
WebIRF6. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … WebJul 5, 2024 · RNA-Seq and KEGG analysis revealed IRF6 downregulates the expression of the PIK3R2 gene, a PI3K regulatory subunit that is comprehensively involved in many cancer-related signaling pathways.
WebStudies have shown that IRF6 is low expressed in gastric cancer , and it has been recently reported that increased IRF6 expression can inhibit the proliferation, invasion and tumorigenicity of breast cancer cells and enhance the sensitivity of tumor cells to chemotherapy drugs . The role of IRF6 in colorectal cancer has not been reported as far ... WebMar 6, 2024 · Using the on-line TCGA database, miRs association network analysis exhibited a total of 11 miRs that are cross-linked with IRF6 in cancer progression (A). qRT-PCR is performed to notarize miR-320 expression (B). Pearson correlation analysis was performed to investigate the association between miR-320 and IRF6 in lung cancer tissues (C).
WebNov 15, 2024 · Figure 2 IRF6 and GRHL3 downregulation in cancer cell lines (A) Panels of cancer cell lines and corresponding normal cells (striped boxes) were screened for IRF6, …
http://www.cancerindex.org/geneweb/IRF6.htm chinese manor houseWebJun 11, 2024 · Lin28A promotes IRF6-regulated aerobic glycolysis in glioma cells by stabilizing SNHG14 - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. chinese mann theater hollywoodWebJun 21, 2024 · The findings of this study indicate that IRF6 is downregulated in highly malignant human and mouse breast cancer cell lines. Also, the modulation of the … grand park city hall weddingWebAug 23, 2013 · Authors. Venkatesh Babu Gurramkonda ; Jyotsna Murthy ; Altaf Hussain Syed ; Bhaskar VKS Lakkakula Sri Ramachandra University Porur, Chennai - 600 116, India ; DOI ... grand park college showcase 2022WebIRF6 is a transcription factor that belongs to a family of nine transcription factors that share a highly conserved helix-turn-helix DNA-binding domain and a less conserved protein … grand park college showcase 2021WebJun 11, 2024 · IRF6 is low-expressed and suppresses proliferation and differentiation in squamous cell carcinomas, such as nasopharyngeal and esophageal cancer, among others 16,17,18. IRF6 induces apoptosis in ... chinese mann theatre hollywoodWebJun 21, 2024 · The downregulation of IRF6 has also been seen in squamous cell carcinomas, 11 nasopharyngeal carcinomas (NPCs), 31 colon and rectal cancer 32 and breast cancer. 33 – 35 Notably, elevated IRF6 protein levels can inhibit tumor malignancy and is associated with good prognosis in NPCs, but the role of IRF6 in the oncogenesis of … grand park city hotel