Small ubiquitin-related modifier 2
WebAbstract. Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembly, protein homeostasis, trafficking ... WebProtein target information for Small ubiquitin-related modifier 2 (tropical clawed frog). Find diseases associated with this biological target and compounds tested against it in …
Small ubiquitin-related modifier 2
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WebNov 26, 2024 · Small ubiquitin-related modifiers (SUMOs) are a group of proteins known to greatly influence various cellular biological processes, 4 such as the cell cycle, signal … WebMay 1, 2009 · The present study aimed to produce and pathophysiologically evaluate the metallothionein (MT) fusion protein. A recombinant plasmid containing DNA segment coding the pET-glutathione transferase (GST)-small ubiquitin-related modifier (SUMO)-MT fusion protein was inserted into Escherichia coli for expression. The expression level of …
WebSep 29, 2024 · Small ubiquitin-related modifier (SUMO) is one such modifier. Therefore, ubiquitination and sumoylation are two post-translational modifications. Ubiquitination marks proteins for degradation. In contrast, sumoylation is not used to mark proteins for degradation. Both modifications regulate protein localization and activity. WebSmall ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma. Data show that substantial increases in the binding of small ubiquitin-like modifier 2 (SUMO-2) to active DNA regulatory elements in response to heat stress.
WebSmall ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene. [5] Function [ edit] This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. WebSUMOylation is a reversible PTM that entails covalent ligation of small ubiquitin-related modifier (SUMO) groups at specific lysine residues. The SUMO family members (SUMO-1, -2, -3, and -4) belong to the group of ubiquitin-like protein-modifying enzymes. Similarly to ubiquitination, SUMOylation is a multistep process that involves an ...
WebAug 10, 2008 · Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men Petrice W. Brown, KeumSil Hwang, Peter N. Schlegel, Patricia L. Morris
UniProt P61956 · SUMO2_HUMAN Protein Small ubiquitin-related modifier 2 Gene SUMO2 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 95 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST … See more This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. 1. Name1 2. See … See more green lanes southgateWebSmall ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma. Data show that substantial increases in the … green lane surgery thrapstonWebFeb 11, 2011 · Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia Under conditions of hypoxia, most eukaryotic cells undergo a shift in metabolic strategy, which involves increased flux through the glycolytic pathway. Although this is critical for bioenergetic homeostasis, the underlying mechanisms have remained incompletely … fly fishing only streams in pennsylvaniafly fishing only signIn molecular biology, SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. This process is called SUMOylation (sometimes written sumoylation). SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional re… green lanes warwickshireWebMar 15, 2012 · SUMO (small ubiquitin-related modifier) conjugation is a reversible three-step process of protein post-translational modifications mediating protein-protein interactions, subcellular compartmentalization and regulation of transcriptional events. Among divergent transcription factors regulated by SUMOylation and deSUMOylation, the … green lane surgery winchmore hillWebOct 12, 2015 · The mouse small ubiquitin-like modifier-2 (SUMO-2) inhibits interleukin-12 (IL-12) production in mature dendritic cells by blocking the translocation of the p65 subunit … fly fishing on the river